5-Amino-1MQ 50mg x 60 Capsules

A Comprehensive Overview for Biological and Medical Researchers

Introduction

5-Amino-1MQ is a small molecule and potent inhibitor of nicotinamide N-methyltransferase (NNMT), a key enzyme that regulates nicotinamide metabolism and S-adenosylmethionine (SAM) utilization. Inhibiting NNMT has shown promise in preclinical studies for improving metabolic efficiency, increasing NAD⁺ levels, reducing fat mass, and modulating age-related cellular decline.

This compound is currently used in in vitro research examining metabolic dysfunction, mitochondrial performance, adipogenesis, aging, and oncogenic methylation pathways.

Chemical Structure and Properties

Product Name: 5-Amino-1MQ

CAS Number: 42464-96-0

Chemical Name: 5-Amino-1-methylquinolinium iodide

Synonyms: 5-Amino-1MQ

Molecular Formula: C₁₀H₁₁IN₂

Molecular Weight: 286.11 g/mol

 IUPAC Name: 5-amino-1-methylquinolin-1-ium iodide

Structure Type: Small molecule (not a peptide)

Mechanism of Action

5-Amino-1MQ targets NNMT, an enzyme that methylates nicotinamide (vitamin B3 derivative), leading to the production of 1-methylnicotinamide (MNA). Inhibiting this pathway has the following effects:

• Elevates NAD⁺ levels by preserving nicotinamide for the salvage pathway.
• Increases S-adenosylmethionine (SAM) availability, supporting global methylation reactions.
• Reduces accumulation of MNA, which has been linked to inflammation and metabolic dysregulation.
• Enhances mitochondrial function and energy metabolism.
• Supports the activity of NAD⁺-dependent enzymes such as sirtuins and PARPs.

Research Highlights

1. Obesity and Metabolism:  In obese mouse models, 5-Amino-1MQ significantly reduced fat mass without affecting food intake, suggesting a direct metabolic effect.  Reference: Neelakantan H. et al., Biochemical Pharmacology, 2018. https://pubmed.ncbi.nlm.nih.gov/29157969/

2. NAD⁺ Restoration and Mitochondrial Support:  Research shows increased NAD⁺ and improved mitochondrial efficiency in tissues after NNMT inhibition. This effect may help reverse cellular aging.  Reference: Wiley C.D. et al., Scientific Reports, 2024.

3. Potential Cancer Research Application:  NNMT is upregulated in various cancers. Inhibitors like 5-Amino-1MQ are being studied for their potential to reverse epigenetic and metabolic shifts in tumor cells.

 Reference: Ulanovskaya O.A. et al., Cell Chemical Biology, 2013. https://pubmed.ncbi.nlm.nih.gov/24360279/

Future Research Applications

• NAD⁺ metabolism and aging research
• Obesity and metabolic syndrome
• Sarcopenia and muscle maintenance
• Epigenetic regulation and methylation studies
• Cancer metabolism and tumor suppression

Chemical Modifications

5-Amino-1MQ is a synthetic derivative of quinoline with a methylated nitrogen at the 1-position and an amino substitution at the 5-position. It is typically formulated as the iodide salt to enhance stability and solubility.

There is no amino acid sequence because this compound is a small molecule, not a peptide.

Usage Information

• Form: Powder or solution
• Purity: ≥98% (HPLC tested)
• Solubility: Soluble in DMSO, limited in water
• Storage: Store at -20°C, protect from light
• Research Use Only: For laboratory use in in vitro studies

Disclaimer

This product is intended for research purposes only. It is not approved for human or veterinary use, nor is it intended for clinical, diagnostic, or therapeutic applications. All research must comply with applicable local laws and institutional guidelines. Misuse of this compound for human consumption is strictly prohibited.