CJC‑1295 (No DAC) + Ipamorelin 5mg Blend

What is the CJC‑1295 (No DAC) + Ipamorelin Blend?

This research-grade peptide blend combines two complementary growth hormone secretagogues:

1. CJC‑1295 (No DAC) – a 29‑amino‑acid modified GHRH analogue designed for enhanced stability and physiological GH pulse stimulation (CAS 863288‑34‑0).
2. Ipamorelin – a selective pentapeptide GHS‑R agonist that triggers acute GH release without affecting cortisol or prolactin (CAS 170851‑70‑4).

When administered in vitro together, they synergistically mimic both hypothalamic GHRH (via CJC‑1295) and ghrelin-mediated GH release (via Ipamorelin), enabling powerful and physiologically relevant modeling of GH axis dynamics (innerbody.com, battlebornresearch.com).

Molecular Identity & Sequences

• • CJC‑1295 (No DAC) (Modified GRF 1–29)
    • Sequence: Tyr‑D‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Gln‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Ala‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Leu‑Ser‑Arg‑NH₂ (peptidesciences.com)
    • CAS: 863288‑34‑0 (chemicalbook.com)
    • M.W.: ~3,367.9 Da; formula: C₁₅₂H₂₅₂N₄₄O₄₂ (cymitquimica.com)

• Ipamorelin

• • Sequence: Aib‑His‑D‑2‑Nal‑D‑Phe‑Lys‑NH₂ (Aib = 2‑aminoisobutyric acid; Nal = naphthylalanine) (pubmed.ncbi.nlm.nih.gov)
  • CAS: 170851‑70‑4 (cymitquimica.com)
  • M.W.: ~711.85 Da; formula: C₃₈H₄₉N₉O₅ (cymitquimica.com)

Both peptides are supplied as HCl salts in lyophilized form, with ≥95–99% HPLC purity per blend specifications (primepeptides.co).

Mechanisms of Action

• CJC‑1295 (No DAC): Binds GHRH receptors on pituitary somatotrophs, eliciting GH release consistent with natural pulsatility. Superior proteolytic stability maintains short-lived but reproducible GH pulses without long-term receptor desensitization (peptidesciences.com).
• Ipamorelin: Selectively activates GHS‑R1a in vitro, causing rapid GH release without triggering cortisol, ACTH, or prolactin secretion—ideal for isolating GH effects (benchchem.com).

Combined, they have been shown to amplify GH secretion, elevate IGF‑1, improve nitrogen balance, and enhance regenerative processes more than either peptide alone (lotilabs.com).

Purported Research Benefits

• Potent GH Pulsatility – mimics endogenous secretion patterns for accurate temporal modeling (en.wikipedia.org).
• IGF‑1 Activation – downstream anabolic effects in muscle, bone, cartilage, and stem cells .
• Tissue Repair & Protein Synthesis – useful in wound healing, hypertrophy, and regeneration models (battlebornresearch.com).
• Metabolic Modeling – allows exploration of lipolysis, glucose uptake, mitochondrial biogenesis, and insulin signaling pathways .
• Neuroendocrine and Circadian Research – supports studies on GH rhythm, hypothalamic feedback, and endocrine regulation .

In Vitro Research Applications

This blend is ideal for:

• Pituitary somatotroph or hypothalamic cell assays monitoring GH release kinetics
• Hepatocyte/myoblast cultures for IGF‑1 signaling and protein synthesis assays
• Fibroblast/endothelial systems in wound-healing or angiogenesis modeling
• Adipocyte models exploring hormonal effects on lipolysis and fat metabolism
• Co-treatment with other agents (e.g., AMPK activators, glucocorticoids) to study multi-pathway interactions

Specifications

Future Research Opportunities

• Quantitative studies on GH pulse frequency and amplitude using HPLC or ELISA
• Combinatorial peptide research with other endocrinologic agents
• Proteomic and transcriptomic profiling post peptide exposure
• Metabolic phenotype assays including glucose and lipid flux measures
• Studies on GH axis regulation in disease models (e.g., sarcopenia, diabetes)

Selected References

1. Loti Labs summary—synergistic GH/IGF‑1 effects of CJC‑1295 and Ipamorelin (lotilabs.com)
2. Innerbody overview of blend mechanisms and benefits in body composition (innerbody.com)
3. ChemicalBook: CJC‑1295 and Ipamorelin mechanisms (GH increase, nitrogen balance) 
4. European J. Endocrinology & PubMed: Ipamorelin GH specificity and receptor binding 
5. Peptide Sciences and Particle Peptides listings confirming sequences and CAS details (peptidesciences.com)

Disclaimer

This product is intended for research purposes only. It is not approved for human or veterinary use, nor is it intended for clinical, diagnostic, or therapeutic applications. All research must comply with applicable local laws and institutional guidelines. Misuse of this compound for human consumption is strictly prohibited.