Epitalon 10mg

What is Epitalon?

Epitalon (also known as Epithalon or Epithalamin peptide; CAS: 307297‑39‑8) is a synthetic tetrapeptide with the amino acid sequence Ala–Glu–Asp–Gly (AEDG) (en.wikipedia.org). It was originally identified as the active component of a bovine pineal gland extract (epithalamin) by the St. Petersburg Institute of Bioregulation & Gerontology (en.wikipedia.org).

Chemical Properties

• Sequence: Ala–Glu–Asp–Gly (AEDG)

• Molecular Formula: C₁₄H₂₂N₄O₉

• Molecular Weight: ~390.35 Da (en.wikipedia.org)

• CAS Number: 307297‑39‑8 (en.wikipedia.org)

• Chemical Structure: A short linear peptide, water‑soluble, presented as lyophilized powder (chemicalbook.com).

Mechanisms of Action

Epitalon has been shown to act through multiple intracellular and epigenetic pathways:

• Telomerase activation and telomere elongation in human somatic cells in vitro, enabling cultures to surpass replicative senescence (en.wikipedia.org).

• Epigenetic modulation via direct binding to histones H1/6 and H1/3, promoting chromatin decondensation and gene reactivation (pmc.ncbi.nlm.nih.gov).

• Antioxidant effects: enhances expression of antioxidant enzymes (e.g., SOD2, catalase) and reduces intracellular ROS (link.springer.com).

• Anti‑apoptotic action: downregulates genes/proteins such as MMP‑9 and caspase pathways, supporting cell survival (particlepeptides.com).

• Chronobiological regulation: stimulates melatonin synthesis and normalizes circadian rhythms (powerpeptides.com).

Research-Based Benefits

• Cellular rejuvenation: Extends lifespan of human fibroblasts in vitro, consistent with Hayflick limit extension (en.wikipedia.org).

• Enhanced wound healing: Restores normal healing and reduces epithelial-mesenchymal transition (EMT) in high-glucose RPE cell models (link.springer.com).

• Chromatin remodeling: Promotes expression of neurogenic markers (e.g., Nestin, GAP‑43) via epigenetic histone interactions (pmc.ncbi.nlm.nih.gov).

• Mitochondrial protection: Improves mitochondrial membrane potential and genomic stability in oocyte and cell models .

In Vitro Research Applications

Epitalon can be used in:

• Senescence and lifespan assays in fibroblast and stem cell cultures

• Oxidative stress and antioxidant gene expression models

• Chromatin remodeling and epigenetic mechanism studies

• Wound healing assays under metabolic stress conditions

• Studies of circadian regulation, melatonin biosynthesis, and neuroprotection

Future Research Directions

• High-content epigenetics: Mapping global histone modification and methylome changes.

• Mitochondrial function: Real-time respiration assays in aged cell models.

• Neurodifferentiation studies: Profiling neuronal lineage commitment in stem cells.

• Comparative telomerase dynamics: Quantitative analyses across cell types and age groups.

• Cancer biology: Investigating cellular response under DNA damage and telomerase reactivation contexts.

Specifications

References

1. Wikipedia entry (Epitalon: structure, sequence, telomerase activity) (en.wikipedia.org, peptidesciences.com, powerpeptides.com)

2. PMC study on gene expression, neuronal differentiation, histone binding 

3. In vitro antioxidant and wound healing in diabetic retinopathy model (link.springer.com)

4. Innerbody summary of melatonin, IL‑2, and antioxidative effects (innerbody.com)

5. Particle Peptides review of telomerase activation and anti-aging mechanisms (particlepeptides.com)

Disclaimer 

This product is intended for research purposes only. It is not approved for human or veterinary use, nor is it intended for clinical, diagnostic, or therapeutic applications. All research must comply with applicable local laws and institutional guidelines. Misuse of this compound for human consumption is strictly prohibited.